psammoma bodies metastatic calcification
1. They have a lamellated concentric calcified structure, sometimes large enough to be seen on CT. With greater degrees of calcification, the density is increased, but usually it suggests that of scattered bismuth or … 1-6 Despite their high specificity in surgical specimens, the predictive value of PB in fine‐needle aspirates (FNA) is uncertain. Kristine on April 29, 2014 at 9:43 am Psammoma bodies are thought by some to represent dystrophic calcification; however, they may be more of an active biological process – see this article for an interesting discussion on the topic. Infarction and calcification of papillae tips. Psammoma bodies, also known as calcospherites and microliths, are laminated, non-birefringent, roughly spheric calcifié parti- cles which measure 5 to 100 y, in diameter. Psammoma bodies are commonly seen in certain tumors such as: Are psammoma bodies due to dystrophic calcification or metastatic calcification? Immunohistochemistry with antibodies to synaptophysin (Dako, Glostrup, Denmark; 1/100 dilution) and chromogranin (Dako; 1/100 dilution) showed cytoplasmic staining. 3. For example, calcification can occur in bronchogenic carcinoma via necrotic degeneration (dystrophic calcification), formation of psammoma bodies (Pb, concentrically laminated calcifications), or engulfment of benign calcified lesions by the carcinoma. It occurs despite normal normal serum calcium & in absence of derangements in calcium metabolism. The features were those of a glandular carcinoid, with extensive psammomatous calcification. Calcifications (psammoma bodies) were noted in 4.7% of serous cystic tumors on CT scans and 14.3% in histopathological studies. Metastatic calcification: The depostion of calium salts in normal tissue. Metastatic calcification. Histologically, calcification was classified as either psammoma bodies, stromal calcification, or bone formation. FIG. Dystrophic calcification: When the depostion occurs in dying tissue, it is known as dystrophic calcification. Ans(Atheroma) 4. CT was not sufficiently sensitive in the detection of intra-cystic calcification in mucinous tumors and psammoma bodies in serous tumors. The strong association between psammoma bodies (PB) and papillary carcinoma (PC) of the thyroid gland has been demonstrated by several histologic studies showing that only 0.05‐1.6% of normal or benign glands have PB, compared with 12‐61% of PCs. Psammoma bodies are associated with the papillary (nipple-like) histo morphology and are thought to arise from, . It is a form of dystrophic calcification. Abundant psammoma bodies were seen throughout the biopsy (fig 1 1).). The psammoma bodies, being very tiny and fairly uniform in distribution throughout the neoplastic region, produce shadows slightly more dense than ordinary soft tissue. Ans(Dystrophic) 3. They have a lamellated concentric calcified structure, sometimes large enough to be seen on CT.. Psammoma bodies are found in a diverse group of tumors which include: Cause. Association with lesions. Psammoma bodies are round microscopic calcific collections. Necrotic cells form the focus for surrounding calcific deposition. Psammoma bodies show which type of calcification: Metastatic; Dystrophic; Secondary; Any of the above . ; Calcification of intralymphatic tumor thrombi. Metastatic calcification is caused by elevated blood calcium / phosphate Stromal calcification may progress to bone formation (Mod Pathol 2009;22:887) It is a form of dystrophic calcification.Necrotic cells form the focus for surrounding calcific deposition. However, in some patients with metastatic papillary cyst- adenocarcinoma of the ovary the diffuse cal- cifications produced by psammoma bodies are characteristic. Dystrophic calcification is seen in: Paget disease; Renal osteodystrophy; Atheroma; Milk-alkali syndrome . Dystrophic calcification of thyroid results from degenerative changes (calcified colloid and degenerated epithelium, psammoma bodies, old hemorrhage, vessel wall, etc.) Psammoma bodies are round microscopic calcific collections.